San Francisco 49ers quarterback Brock Purdy can he lead the charge against the Los Angeles Rams at Melbourne Cricket Ground Stadium in Melbourne Australia on Thu Sep 10, 2026 at 5:35pm P/ (AP file photo)

San Francisco 49ers podcast David Zizmor:

#1 Can Brock Purdy lead the 49ers offense to a win over the Rams in the season opener?

#2 How effective will Christian McCaffrey be against the Rams’ defense?

#3 Will Nick Bosa make a major impact in his return from his ACL injury?

David Zizmor does the San Francisco 49ers podcasts after each home and away game at http://www.sportsradioservice.com