San Francisco 49ers quarterback Brock Purdy (left) talks things over with tight end George Kittle (right) during practice with the Los Angeles Chargers at El Segundo CA on Aug 18, 2026 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 Can the San Francisco 49ers’ defense contain the Rams’ star-studded offense in the historic Australian opener Thu Sep 10 at 5:35pm PDT?

#2 Will the San Francisco 49ers’ health and depth hold up after the long trip Down Under?

#3 Which key matchup will decide the San Francisco 49ers vs. Los Angeles Rams clash in Melbourne?

David Zizmor does the San Francisco 49ers podcasts each week at http://www.sportsradioservice.com