San Francisco 49ers podcast David Zizmor: Will injuries have an impact on 49ers as they meet Cardinals Sunday

San Francisco 49ers running back Christian McCaffrey (23) gives thanks to the Almighty after scoring a touchdown against the New York Giants in the fourth quarter Sun Nov 2, 2025 in East Rutherford NJ (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 With Christian McCaffrey still being one of the most versatile offensive weapons in the league, how will the 49ers deploy him against Arizona’s front-seven—and can he exploit any running-lane weaknesses in the Cardinals’ defense?

#2 Given that Mac Jones has been the primary quarterback this season (while Brock Purdy remains uncertain/injured) for San Francisco with 2,151 passing yards so far this year, how might the change in signal-caller impact the 49ers’ offensive rhythm and decision-making?

#3 On the defensive side, how well can the 49ers limit the Cardinals’ offense—especially in the passing game, given Arizona is allowing about 223.7 yards per game through the air so far?

David Zizmor does the San Francisco 49ers podcasts Wednesdays at http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: QB Jones converts most of his passes; Pearsall makes practice for second straight day; plus more Niner news

 San Francisco 49ers quarterback Brock Purdy (13) works on passing drills during the first day of training camp at SAP Performance Facility. Mandatory Credit: D. Ross Cameron-Imagn Images / D. Ross Cameron-Imagn Images

San Francisco 49ers podcast David Zizmor:

#1 San Francisco 49ers back up quarterback Mac Jones threw 14 of 18 passes with no interceptions. Jones threw for a bunch of completions including a 30 yard pass to Demarcus Robinson, a 20 yarder to Equanimeious St. Brown who ran a corner route. Jones’ performance is accurate and completed 77% of his passes in five practices.

#2 Wide receiver Rickey Pearsall was at practice for the second straight day. Pearsall at 11 on 11 drills caught two passes. Pearsall didn’t practice in the second half or in 1 on 1 drills. The 49ers are using Pearsall cautiously after his coming off a hamstring injury.

#3 Wide receiver Jauan Jennings who is suffering from a calf injury from the off season didn’t show up to practice on Sunday. Jennings was wondering if that was calf injury or an Achillies injury. Christian McCaffrey had a calf strain and it turned out to be Achillies tendonitis. The 49ers are being cautious about Jennings if it’s a calf or Achillies.

David Zizmor does the San Francisco 49ers podcasts Wednesdays at http://www.sportsradioservice.com

San Francisco 49ers podcast with David Zizmor: Roster moves made; Montana says Jones is the better choice than Lance; plus more

San Francisco 49ers quarterback Trey Lance (5) tries to skirt around Arizona Cardinal free safety Jalen Thompson (34) during Sun Oct 10, 2021 game at State Farm Stadium. Former 49ers quarterback Joe Montana said that New England Patriots quarterback Mac Jones would have been a better pick than Lance. (AP News photo file)

On the 49ers podcast with David:

#1 Tuesday was a busy day at the San Francisco offices at the Marie DeBartolo Complex in Santa Clara as the 49ers (3-4) have made some roster moves as follows, acquired defenseman Charles Omenihu, linebacker Tyrell Williams released, kicker Joey Slye wavied, and safety Kai Nacua has been moved to the practice squad.

#2 Dave, former San Francisco 49ers quarterback and legend Joe Montana said he would have taken the New England Patriots quarterback Mac Jones over 49ers back up Trey Lance. Jones so far this season is piling up on the yards at 1,997, nine touchdowns, six interceptions, for Lance 354 yards, three touchdowns, and an interception this season. Where do you stand on Montana’s choice of quarterbacks?

#3 Dave after losing four straight and going into Chicago with a 33-22 win has 49ers quarterback Jimmy Garoppolo turned a corner, critics still are calling for Lance to be the starting quarterback.

Join David for the 49ers podcasts each Wednesday at http://www.sportsradioservice.com