San Francisco 49ers podcast David Zizmor: Will injuries have an impact on 49ers as they meet Cardinals Sunday

San Francisco 49ers running back Christian McCaffrey (23) gives thanks to the Almighty after scoring a touchdown against the New York Giants in the fourth quarter Sun Nov 2, 2025 in East Rutherford NJ (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 With Christian McCaffrey still being one of the most versatile offensive weapons in the league, how will the 49ers deploy him against Arizona’s front-seven—and can he exploit any running-lane weaknesses in the Cardinals’ defense?

#2 Given that Mac Jones has been the primary quarterback this season (while Brock Purdy remains uncertain/injured) for San Francisco with 2,151 passing yards so far this year, how might the change in signal-caller impact the 49ers’ offensive rhythm and decision-making?

#3 On the defensive side, how well can the 49ers limit the Cardinals’ offense—especially in the passing game, given Arizona is allowing about 223.7 yards per game through the air so far?

David Zizmor does the San Francisco 49ers podcasts Wednesdays at http://www.sportsradioservice.com

SF 49ers podcast with David Zizmor: Rams pulverize 49ers in crushing 42-26 defeat in Santa Clara

Los Angeles Rams quarterback Matt Stafford points in the direction where he wants his offense to go against the San Francisco 49ers defense at Levis Stadium in Santa Clara on Sun Nov 9, 2025 (AP News photo)

San Francisco 49ers podcast with David Zizmor:

#1 The San Francisco 49ers (6-4) got pulverized by the Los Angeles Rams (7-2) by nothing close 42-26. The Rams quarterback Matt Stafford had all day to throw and got great protection. Stafford was 24-26 for 280 yards and four touchdowns.

#2 Meanwhile 49ers quarterback Mac Jones had troubles trying to keep up with the Rams on the scoreboard and wasn’t able to connect to receivers as much as he would throwing 33-39 for 319 yards and three touchdowns.

#3 Up next for the 49ers it’s off to Arizona and State Farm Stadium in Glendale to face Arizona Cardinals quarterback Jacoby Brissett. The Cardinals lost a tough one on Sunday to the Seattle Seahawks getting 22 point beat down losing 44-22. How do you see this one next Sunday in Arizona?

Join David Zizmor for the San Francisco 49ers podcast after every home and away game at http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: 49ers blitzed with loses of Purdy game to game and Williams for rest of season

San Francisco 49ers quarterback Brock Purdy will most likely miss the rest of the season due to turf toe injury. Purdy (right) is seen here speaking with Houston Texans quarterback CJ Stroud (7) following their game in Houston on Sun Oct 26, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 San Francisco 49ers head coach Kyle Shanahan said for the first time that Brock Purdy is most likely lost for the rest of the season due to his turf toe injury.

#2 Purdy has now missed the last five games backed up Mac Jones has stepped in and stepped getting wins and threw for 235 yards and two touchdowns last Sunday against the New York Giants last Sunday.

#3 Dave the Los Angeles Rams are up next Sunday Nov 9th at Levi Stadium in Santa Clara a 1:25pm PT. Besides losing PurdyTalk about the 49ers losing rookie defensive end Mykel Williams and how this will impact their game against the Rams this Sunday?

David Zizmor does the 49ers podcasts Wednesdays at http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: 49ers take advantage of struggling Giants in 34-24 win at the Meadowlands

San Francisco 49ers running back Christian McCaffrey (23) stiff arms the New York Giants cornerback Andru Phillips in the third quarter at Met Life Stadium in East Rutherford NJ on Sun Nov 2, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 A whole lot better game for the San Francisco 49ers (6-3) after last week’s game in Texas. 49ers quarterback Mac Jones who threw for two touchdowns and over 235 yards passing against the New York Giants (2-7).

#2 The 49ers dominated on both sides of the football in both halves and got some offense on the ground from running back Christian McCaffrey who ran for 97 yards and scored a touchdown. On receiving yards again McCaffrey multi tasking with 67 yards and a wide out touchdown.

#3 Next up for San Francisco the Los Angeles Rams. Although the Rams had won two of the last three games they did lose to the 49ers the last time they met 26-23 at So Fi Stadium on October 2. This Sun Nov 9 the Rams come to Santa Clara to do battle with the 49ers how do you see this match this time?

Join David Zizmor for the 49ers podcasts after every home and away game at http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: White joins 49ers to shore up at defensive end; 49ers try to get back in win column face Giants Sunday

Defensive end Kieon White joins the San Francisco 49ers after playing for the New England Patriots. White will join the 49ers in the Meadowlands Sun Nov 2, 2025 against the New York Giants (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 Was the loss to the Houston Texans last week just a game that could be written off a just a bad week for the 49ers and looked as a turn the page moment?

#2 We talked about quarterback Mac Jones that it was a bad afternoon for him. Was it a matter of the Texans doing their home work studying video on the 49ers or Jones was couldn’t get on track?

#3 The New York Giants the 49ers next opponent have lost their last two game in a row. they dropped their record to 2-6. They’re a struggling bunch do you see any chance that the 49ers could have a tough afternoon with the Giants at Met Life in the Meadowlands on Sunday or should this one be a breeze for San Francisco?

David Zizmor does the San Francisco 49ers podcasts each Wednesday at http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: Not enough offense buries 49ers 25-16; Texans’ Stroud throws for 318 yards

San Francisco 49ers quarterback Mac Jones (10) throws against the Houston Texans pass rush in the second half at NRG Stadium in Houston on Sun Oct 26, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 San Francisco 49ers (5-3) Mac Jones couldn’t get his passes where he wanted them in the end zone. Jones threw 19-32, 193 yards and one touchdown.

#2 Texans quarterback CJ Stroud scored in low or medium numbers but good enough to hold the 49ers back for the 25-16 win. Stroud led the Texans going 30-39 for 318 yards and two touchdowns and threw one interception.

#3 Up next up for the San Francisco 49ers it’s off to the Meadowlands and the New York Giants (2-6) the Giants have lost his last three of their last four games. The Giants took a tough loss on Sunday to the Philadelphia Eagles 38-20. Can the 49ers overcome Sunday’s tough loss next Sunday at Giants Stadium.

Join David Zizmor after each home and away 49ers game at http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: 49ers hit the road against Texans this Sunday

San Francisco 49ers quarterback Mac Jones (15) can’t get a pass off as the Atlanta Falcons Leonard Floyd puts the pressure on Jones in the second quarter at Levi Stadium in Santa Clara on Sun Oct 19, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 How did San Francisco 49ers running back Christian McCaffrey’s performance—129 rushing yards and 201 yards from scrimmage—change the offensive dynamic for the 49ers and what does that suggest about their run game moving forward?

#2 Dave, talk about the job quarterback Mac Jones who threw for 17-26 for 152 yards, no touchdown passes and one interception to help the 49ers with a 20-10 win on Sunday Night Football?

#3 The 49ers head to Houston to take on the Texans (2-4) on Sun Oct 26th with a 10:00AM PT. The Texans were beat on Monday Night Football 27-19 by the Seattle Seahawks. Texans quarterback CJ Stroud struggled under center throwing 23-49, 229 yards and one pick. Talk about how you see this match up Sunday with the Niners and Texans.

Join David Zizmor does the 49ers podcast each Wednesday at http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: McCaffrey 201 yards rushing helps defeat Atlanta 20-10

San Francisco 49ers running back Christian McCaffrey (23) rushes past Atlanta Falcons linebacker Kaden Elliss (55) in the second quarter at Levi Stadium in Santa Clara on Sun Oct 19, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 San Francisco 49ers (5-2) running back Christian McCaffrey ran his first 100 yard game since he did it back in 2023.The 49ers also who were missing a lot of their starters pulled off a ten point win over the Atlanta Falcons (3-3) on Sunday Night Football 20-10.

#2 McCaffrey ran for 129 yards and two touchdowns and had 201 total yards and did it all from scrimmage. The last time McCaffrey had a 200 yard game was in 2019.

#3 The 49ers are in Houston to take on the Houston Texans (2-3). The Texans clobbered the Baltimore Ravens 44-10 back on Sun Oct 5th and after a bye are back to face the Seattle Seahawks on Monday Night Football in Seattle. How do you see this match up in Texas for Sun Oct 26th for the 49ers?

David Zizmor does the San Francisco 49ers podcasts each Sundays at http://www.sportsradioservice.com

 

San Francisco 49ers podcast David Zizmor: 49ers shore up their defense; Injury plagued team takes precaution in defensive signings

San Francisco 49ers offensive lineman Isaac Alarcon was added by the practice squad on Tue Oct 14, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 The San Francisco 49ers added to their practice squad by re-signing offensive lineman Isaac Alarcon, defensive end Robert Beal. The 49ers also announced that they have released defensive tackle Bruce Hector from the practice squad. The 49ers are looking for ways at bringing the next man up with the multiple injuries that they have been having.

#2 The 49ers are also taking a look at three defensive backs Shamar Bartholomew and Isaac Bolden, tackle Andre Dillard, and defensive back Tre Hawkins. This no doubt is an indication that the 49ers are also concerned about protecting their defense back field.

#3 On Sunday Night Football the 49ers host the Atlanta Falcons Oct 19 at Levis Stadium in Santa Clara at 5:20pm PT The Falcons are 3-2. The Falcons have also won their last two games last Sunday against the Buffalo Bills and the week before against the Washington Commanders. How do you see this match up on prime time TV Sunday night?

David Zizmor is a San Francisco 49ers analyst for http://www.sportsradioservice.com

San Francisco 49ers podcast David Zizmor: Injuries piling up Warner out for season ankle injury; Purdy, Kittle, Jennings could be back Sunday; Niners lose in Tampa 30-19

San Francisco 49ers linebacker Fred Warner (right) is carted off the field with a season ending ankle injury against the Tampa Bay Buccaneers at Raymond James Stadium in Tampa Bay on Sun Oct 12, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 David, San Francisco 49ers (4-2) quarterback Mac Jones was 27-39 for 347 yards and was picked off two times in the loss Sunday to the Tampa Bay Buccaneers (5-1).

#2 In the second half of the game the 49ers just couldn’t get any offense going it was 10-3 Bucs in the second half and the 49ers got shutout in the fourth quarter.

#3 Up next for the 49ers they host the Atlanta Falcons (2-2) on Sun Oct 19. The Falcons who defeated the Washington Commanders at Mercedes Benz Stadium in Atlanta 34-27 on Sun Sep 28 and play the Buffalo Bills on Monday Night Football. Will this be a different opponent a team the 49ers might be able to handle this next game.

San Francisco 49ers podcasts are heard after every home and away game with David Zizmor at http://www.sportsradioservice.com