San Francisco 49ers quarterback Brock Purdy threw for five touchdown passes against the Indianapolis Colts on Monday Night Football Dec 22, 2025 at Lucas Oil Stadium in Indianapolis (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 Christian McCaffrey has been a central part of San Francisco’s offense, posting over 1,000 rushing yards and contributing heavily as a receiver, making him a dual-threat that defenses must plan around. How will the Bears’ defense handle 49ers star RB McCaffrey?

#2 Can Brock Purdy and the 49ers’ passing attack overcome Chicago’s pass rush and ball hawking defense?

#3 49ers tight end Goerge Kittle has been a key offensive weapon for San Francisco, and his status or performance could shape how the 49ers attack against the Chicago defense. What impact will 49ers Kittle’s health have on the game?

David Zizmor does the San Francisco 49ers podcasts each Wednesday at http://www.sportsradioservice.com