San Francisco 49ers quarterback Brock Purdy (13) throws a pass against the Cleveland Browns on Sun Nov 30, 2025 at Huntington Bank Field in Cleveland. The 49ers could go into their bench if they overwhelm the Tennessee Titans this Sun Dec 14, 2025 at Levi Stadium (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 Can Brock Purdy bounce back and lead the 49ers’ offense after the bye week against the Titans’ defense?

#2 How will Christian McCaffrey and Kyle Juszczyk be used to exploit Tennessee’s run defense — will the 49ers lean on the ground game?

#2 With pass-rush numbers down for San Francisco this season, can Nick Bosa pressure the Titans’ quarterback enough to disrupt their offense?

David Zizmor does the 49ers podcasts each week at http://www.sportsradioservice.com