San Francisco 49ers quarterback Brock Purdy (13) is thrilled after the 49ers defeated the Cleveland Browns at Huntington Bank Field in Cleveland on Sun Nov 30, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 With Christian McCaffrey healthy and expected to feature prominently in the run game, how might his usage shape the 49ers’ offensive strategy against the Titans’ defense on Sun Dec 14?

#2 Can Brock Purdy — given his recent performances — build on momentum in the passing game to exploit Tennessee’s secondary, or will the 49ers lean more on their ground attack with McCaffrey?

#3 Considering the 49ers’ offensive line and running back depth beyond McCaffrey, Isaac Guerendo, Jordan James, how might they balance carries and keep the offense fresh against a physical Titans front?

Join David Zizmor for the San Francisco 49ers podcasts each Wednesday at http://www.sportsradioservice.com