San Francisco 49ers running back Christian McCaffrey (23) gives thanks to the Almighty after scoring a touchdown against the New York Giants in the fourth quarter Sun Nov 2, 2025 in East Rutherford NJ (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 With Christian McCaffrey still being one of the most versatile offensive weapons in the league, how will the 49ers deploy him against Arizona’s front-seven—and can he exploit any running-lane weaknesses in the Cardinals’ defense?

#2 Given that Mac Jones has been the primary quarterback this season (while Brock Purdy remains uncertain/injured) for San Francisco with 2,151 passing yards so far this year, how might the change in signal-caller impact the 49ers’ offensive rhythm and decision-making?

#3 On the defensive side, how well can the 49ers limit the Cardinals’ offense—especially in the passing game, given Arizona is allowing about 223.7 yards per game through the air so far?

David Zizmor does the San Francisco 49ers podcasts Wednesdays at http://www.sportsradioservice.com