San Francisco 49ers head coach Kyle Shanahan (left) prepares his team against the Los Angeles Rams at SoFi Stadium in Los Angeles on Thursday Night Football on October 2, 2025 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 How did Jacksonville’s defense exploit the absence of 49ers DE Nick Bosa, and can San Francisco adjust to compensate in their next game and now Ricky Piersall, Jauan Jennings, and Brock Purdy are out with injuries for Thursday night.

#2 Given the pregame accusations of “legal signal‑stealing” from Robert Saleh, how might both teams manage their communication, audibles, and pre‑snap adjustments?

#3 Which offensive strategy was more effective — Jacksonville was leaning heavily on the run game from running back Travis Etienne or San Francisco pushing through the air via McCaffrey and short passes — given each defense’s strengths?

#4 Get your thoughts as 49ers get ready for Thursday Night Football in Los Angeles against the LA Rams.

David Zizmor does the San Francisco 49ers podcasts each Wednesday at http://www.sportsradioservice.com