Jacksonville Jaguars Parker Washington returns a punt against the San Francisco 49ers punter Thomas Morstead (7) and Isaac Guerendo (31) during second half at Levi Stadium in Santa Clara on Sun Sep 28, 2205 (AP News photo)

San Francisco 49ers podcast David Zizmor:

#1 The Jacksonville Jaguars defense held off the San Francisco 49ers offense for much of the game on Sunday to get their third win of the season defeating the 49ers in Santa Clara 26-21.

#2 It was the return of 49ers quarterback Brock Purdy who threw 22-38 for 309 yards, two touchdowns and two interceptions. In spite of his efforts the 49ers fall by a touchdown for their first loss of the season.

#3 Jacksonville quarterback Trevor Lawrence was 21-31 for 174 yards and a touchdown. It was the second quarter when Jacksonville scored 17 points that was really the difference.

#4 For the 49ers running back Christian McCaffrey he tallied 49 yards in 17 carries is there still speculation he’s playing with pain?

#5 Next up for the 49ers the Los Angeles Rams long time rival. The Rams won 27-20 defeating the Indianapolis Colts at Indianapolis today. The Rams improve their record to 3-1. 49ers head to Los Angeles for Thursday Night Football on Oct 2 for a 5:15pm kick off how do you see those two teams matching up?

David Zizmor is an NFL analyst for http://www.sportsradioservice.com