Seattle Seahawks linebacker Boye Mafe (53) chases San Francisco 49ers quarterback Brock Purdy (13) who runs for his life in the second half of action at Levi Stadium in Santa Clara on Sun Nov 17, 2024 Purdy’s last game before he was out with injury. (AP News photo)

San Francisco 49ers podcast with Jeremey Harness:

#1 What it got to be like for the 49ers to facing the Buffalo Bills this Sunday on the first day of December without four of their pro bowlers?

#2 49ers head coach Kyle Shanahan said that “It’s nice when your one game out of first place in your own division.” Despite the 49ers recent troubles missing star players and quarterback Brock Purdy playing hurt.

#3 The 49ers coming into Buffalo at 5-6. The Buffalo Bills handed the Kansas City Chiefs their first loss on Nov 17th 30-21. The Bills are not only tough at home but their seven game over .500 at 9-2. This no doubt will be one of the toughest games of the season for San Francisco especially with quarterback Brock Purdy in question.

Jeremy Harness filled in for David Zizmor for the San Francisco 49ers podcast heard every Wednesday at http://www.sportsradioservice.com