San Francisco 49ers quarterback Jimmy Garoppolo (10) who was sacked on this play by the Seattle Seahawks Bobby Wagner in the first half at Centurylink Field in Seattle on Sun Oct 25, 2020 (AP News photo)

On the 49ers podcast with Dave:

#1 Dave how difficult does it get for the 49ers now that quarterback Jimmy Garoppolo is out for six weeks with a reinjured high ankle sprain and tight end George Kittle out eight weeks with a fractured foot injury.

#2 The 49ers last game in Seattle saw the Seahawks get 24 points in the second half as the 49ers tried to rally from behind with 20 points falling short in the fourth quarter.

#3 The 49ers have that short turnaround after playing in Seattle on Sunday and now they host the Green Bay Packers on Thursday Night Football but with the injuries the 49ers have it could be another long night for them.

David Zizmor does the 49ers podcast each Wednesday morning at http://www.sportsradioservice.