The San Francisco 49ers Marcell Harris knocks the ball out of the hands of the New York Giants Darius Slayton last Sun Sep 27, 2020 at Metlife Stadium in East Rutherford NJ. The 49ers host the Philadelphia Eagles on Sunday Night Football Sun Oct 4, 2020 (AP News photo)

By Jeremiah Salmonson

SANTA CLARA–The San Francisco 49ers are back at it on Sunday. Last week, the 49ers were able to pull out a win in New York against the Giants despite injuries to the running back core, quarterback, tight end, and wide receiver. This week they take on the winless Philadelphia Eagles.

The Eagles are injured. The 49ers are injured. The Eagles are dealing with notable injuries to DeSean Jackson and Dallas Goedert. The jury is still out on if Jackson will play Sunday but it looks unlikely.

For San Francisco, the injuries are also piling up. Notably RB Raheem Mostert will be out, WR Deebo Samuel will be out, TE George Kittle most likely out, and QB Jimmy Garoppolo will also most likely be out. It is possible the Garoppolo and Kittle both return in week four on Sunday but that remains unlikely.

In order for the 49ers to win they will need a repeat performance from backup QB Nick Mullens. Last week Mullens threw for almost 350 yards with a touchdown. Another key price will be rookie WR Brandon Aiyuk. Aiyuk impressed last week and could be another key piece on Sunday.

Overall, it looks like a good chance the 49ers will be able to pull out a win. The Eagles have really struggled this year and don’t show many signs of turning it around.

The game starts at 5:20 PM PST on Sunday night. Watch on NBC Sunday Night Football.