AP File Photo: Indianapolis Colts running back Frank Gore (23) goes over Cleveland Browns middle linebacker Joe Schobert (53) during the first half of an NFL football game in Indianapolis, Sunday, Sept. 24, 2017. (AP Photo/AJ Mast)

 By Jeremy Harness

 SANTA CLARA–If there was a chance for the 0-4 49ers to get their first win of the season, Sunday presents that.

 They are coming off a loss to the Arizona Cardinals, a game which saw the team blow a golden opportunity to win the game in overtime only to have the other team make the big play that the 49ers again failed to make.

 Opportunities could be running out on this team quickly, with the best one coming on Sunday against the 1-3 Indianapolis Colts.

 The Colts have been without starting quarterback Andrew Luck this season, and even though he did practice on Wednesday, it was on a limited basis and is expected to miss Sunday’s game. That means the Colts will go with backup Jacoby Brissett to face the 49ers.

 Also seeing the 49ers on Sunday is Frank Gore, the longtime San Francisco great who has spent the past few years in Indianapolis to continue his storied career.

 His protégé, 49ers back Carlos Hyde, has been nursing a hip injury this season and although he is expected to play against the Colts, he was limited in practice on Wednesday.

 The 49ers are expected to be without linebacker Reuben Foster – who has been out since Week 1 with a high ankle sprain – and safety Eric Reid, who suffered a knee injury in Week 2 at Seattle, for another week, as both players did not practice on Wednesday.

 Receiver Marquise Goodwin suffered a concussion last week against Arizona but was able to practice Wednesday, although it was on a limited basis.