AP photo: The last time Colin Kaepernick saw action was in this Sep 1st photo when he faced San Diego Chargers in pre season play he’ll get a full game out of the Buffalo Bills on Sunday

On the podcast with Joe:

This is it the San Francisco 49ers quarterback Colin Kaepenick gets the call for this Sunday’s game against the Buffalo Bills there’s a lot of anticipation going into this one to see how well Kaepenick will perform in his first start of the season. The 49ers have struggled since opening day and dropping four straight is a huge concern now for head coach Chip Kelly and Joe takes a look at some of those concerns.

Last week the Arizona Cardinals picked off 49er quarterback Blaine Gabbert twice and he was sacked seven times Joe takes a  look at the what kind of protection the offensive line will offer up to protect Kaepernick. Also Joe matches up the Buffalo Bills and 49ers for Sunday’s picks

Joe Lami does the 49ers podcasts each week at http://www.sportsradioservive.com