San Francisco Giants Mike Yastrzemski (left) is greeted by teammate Mike Tauchman (right) after hitting a three run homer in the seventh inning. St Louis Cardinals catcher Yadier Molina (center) can only look at the scoreboard replay (AP News photo)

By Jeremy Kahn

What a way for the San Francisco Giants than with a huge win on the road against a team that just beat them two out of three.

Mike Yastrzemski hit two home runs and LaMonte Wade, Jr., added one of his own, as the Giants took game one of a three-game series with a 7-2 victory over the St. Louis Cardinals at Busch Stadium. It was the fifth win in a row for the Giants, who continue to lead the Los Angeles Dodgers by two games and the San Diego Padres by six games in the National League West, and continue to have the best record in the major leagues with a record of 58-32.

Logan Webb started in place of Kevin Gausman, who was placed on the Family Medical List prior to the game.

Gausman stayed in his home state of Colorado due to an emergency and it is unclear when he will rejoin the team.

Webb, who was scratched from his start with the Single-A San Jose Giants went four innings, allowing one run on five hits, walking one and striking out two, as he threw 60 pitches, as he continues rehab from his shoulder strain injury earlier in the season.

Following Webb on the mound was Zach Littell, John Brebbia, Jarlin Dominic Leone, Jay Jackson and finally Tyler Rogers.

The sextet went the final five innings, allowing one run on six hits, walking three and striking out seven and Jackson picked up his first win of the season, as he pitched 1.1 innings, allowing just one walk and striking out two.

Yastrzemski gave the Giants an early lead in the top of the fourth inning, as he hit his 13th home run, a solo home run off of Adam Wainwright.

Unfortunately, that lead would not last long, as Tommy Edman drove in Nolan Arenado with a single in the bottom of the fourth inning.

Wade, Jr., decided that the tie needed to go away, as he slammed a three-run home run in the top of the fifth inning that gave the Giants the lead for good. It was the eighth home run of the season for Wade, Jr.

Yastrzemski added his second home run of the night that blew the game wide open, as he hit a three-run home run of his own in the top of the seventh inning to give the Giants a 7-1 lead over the home standing Cardinals.

Paul Goldschmidt hit his 14th home run of the season in the bottom of the seventh inning to the final touches on the scoring on the evening. Brandon Crawford was forced to leave the game early with what Giants manager Gabe Kapler said what was a left hamstring cramp, he received fluids and will be checked out prior to the game on Saturday.

NOTES: Asides from Gausman going on the Family Medical Emergency List, Jason Vosler was optioned to Sacramento and Evan Longoria was transferred to the 60-day Disabled List. Mike Tauchman returned from his rehab assignment and was reinstated from the 10-day injured list.

With three more home runs tonight, the Giants have hit 135 home runs on the season and are tied for the major-league lead with the Toronto Blue Jays, who have also hit 135 home runs after they hit five home runs in a 10-2 victory over the Texas Rangers at Sahlen Field in Buffalo, N.Y.

UP NEXT: Anthony DeSclafani will make the start for the Giants on Saturday, while the Cardinals will send Kwang Hyun Kim to the mound.