San Diego Padres Manny Machado gives thanks to the Almighty after hitting a three run home run against the San Francisco Giants in the first inning at Petco Park in San Diego on Sat May 1, 2021 (AP News photo)

By Jeremy Kahn

Manny Machado came up with the biggest hit of the night for the San Diego Padres, and it was able to stick.

Machado hit a three-run home run off of Anthony DeSclafani in the bottom of the first inning, as the Padres defeated the San Francisco Giants 6-2 at Petco Park.

The Machado home run held up, as Blake Snell went five innings, two runs (one earned), walking three and striking out six on his way to his first win as a member of the Padres.

Trent Grisham led off the bottom of the first inning with a single and then Fernando Tatis, Jr., before Machado launched a three-run home run into the left-center field seats and the Padres never looked back.

After that nightmarish first inning, DeSclafani did not allow a run, gave up a hit, walked one and struck out three in his final five innings of work.

Overall, DeSclafani went six innings, allowing three runs on three hits, walking two and striking out three and he lost for the first time as a member of the Giants.

Mauricio Dubon got the Giants on the board in the top of the fifth inning, as he hit a solo home run to lead off the inning. It was the first home run of the season for Dubon, who also picked up his seventh run batted in of the season.

Darin Ruf cut the Padres down to one run, as he singled off of Snell to score DeSclafani, who reached on a fielding error by Snell. That would be as close as the Giants would get on the evening.

Jurickson Profar put the game out of reach in the bottom of the eighth inning, as he a pinch-hit home run off of Zack Littell.

Jake Cronenworth added on some insurance, as he hit a two-run single off of Jose Alvarez that scored Tatis, Jr., and Eric Hosmer.

NOTES: Through 27 games, the Giants have made only seven errors, the fewest errors of any team in major league baseball.

UP NEXT: Kevin Gausman looks to stop the bleeding on Sunday, as he takes the Petco Park mound, as the Giants look to avert the sweep.