San Diego Padres’ Manuel Margot, center, is congratulated in the dugout after hitting a three-run home run against the San Francisco Giants during the fourth inning of a baseball game Tuesday, Aug. 29, 2017, in San Diego. (AP Photo/Orlando Ramirez)

By Jeremy Kahn

Things started out good for the San Francisco Giants, especially after they took an early 2-0 lead over the San Diego Padres.

Unfortunately, it was not meant to be, as rookie Manuel Margot hit a three-run home run off of Matt Moore in the bottom of the fourth inning and the Padres came back to defeat the Giants 6-3 at Petco Park.

It was the 13th home run of the season for Margot, as he helped Luis Perdomo picked up the victory.

Perdomo went six innings, allowing two runs (one of them earned), he also allowed eight hits, walked two and struck out three, as Perdomo worked at least six innings for the eighth consecutive start.

Brad Hand was the final of three relievers for the Padres, as he pitched the ninth inning for his 13th save of the season.

As for the Giants, this was their 81st loss of the season, meaning that they would have to win 28 straight just to get to the .500 mark. The major-league record for consecutive wins is 26, held by the Giants.

This was the fourth loss in the Giants last five games, as the Padres continue their dominance over the Giants, as they have won eight out of their last 11 versus them.

The nightmarish season for Moore continues, as his record on the season falls to 4-13. Moore gave up five runs and eight hits, walking one and striking out two.

Asides from the Margot three-run home run, Moore gave up a solo home run to Jabari Blash that tied up the game.

The Giants got on the board in the top of the second inning, as they were helped out by errors, courtesy of the Padres.

Cory Spagenberg committed a throwing and fielding error that helped the Giants scored two early runs versus Perdomo.

Joe Panik got the inning started, as he singled off of Perdomo and then Nick Hundley reached on a fielding error by Spangenberg. Moore helped out his own cause, as his sacrifice bunt ended up in a single and Spangenberg’s throwing error allowed Panik to score.

Denard Span, who picked up three hits on the evening, drove in the second run of the inning with a single.

Panik closed out the scoring for the Giants, as he hit a solo home run in the top of the eighth inning; however, they were not able to get any closer.

NOTES: Ty Blach closes out the road trip, as he takes the mound for the Giants on Wednesday, while the Padres will send Travis Wood to the mound.

Buster Posey missed his second straight game, as he is nursing a sprained left thumb and it is doubtful that he will play on Wednesday.