By Jeremy Kahn

AP photo: Toronto Blue Jays Troy Tulowitzki slides in safe as San Francisco Giant catch Buster Posey is late putting down the tag on Tuesday night at AT&T Park

SAN FRANCISCO-Matt Cain looked like his old self with the exception of a pitch to Troy Tulowitzki on a 2-1 pitch in the top of the second inning.

Tulowitzki launched the Cain offering into the left field bleachers, helping the Toronto Blue Jays to a 4-0 victory over the San Francisco Giants before a crowd of 41,464, the 428th consecutive sellout at AT&T Park.

It was the sixth career home run for Tulowitzki off of Cain.

Tulowitzki added a sacrifice fly in the top of the seventh inning that scored Michael Saunders from third base after the left fielder tripled to right-center field with one out.

Once again, Tulowitzki was at again in the top of the ninth inning, as he doubled in pinch runner Ezequiel Carrera and then Russell Martin closed out the scoring, when singled in Tulowitzki.

The other big story for the Blue Jays was the pitching of left-hander J.A. Happ, who allowed zero runs on just six hits in eight and two-third innings of work, as the Blue Jays made it two straight over the Giants.

Happ did not allow a hit to the Giants until Kelby Tomlinson beat out a bunt single with one out in the bottom of the third inning; however Tomlinson was caught stealing at second base for the second out of the frame and then Cain ended the inning on a ground out to Josh Donaldson at third base.

This was Happ’s first career win versus the Giants in five career starts, as he was 0-4 coming into the game. Happ last faced the Giants on June 16, 2015 as a member of the Seattle Mariners.

As a matter of fact, Happ was the losing pitcher for the Houston Astros when Cain threw the only perfect game in Giants history on June 13, 2012.

It was a tough loss for Cain, who went eight innings, allowing two runs on seven hits, while not walking a batter and striking out seven, and saw his record fall to 0-5 on the season.

The Giants base running gave another away a huge opportunity in the bottom of the fourth inning, as Denard Span walked to leadoff the inning and then Joe Panik hit a sinking line drive into left field that Saunders was unable to haul in; however Saunders was able to recover and throw to Ryan Goins at second base for the first out of the inning.

Unfortunately, the inning ended, when Buster Posey hit into a nifty double play that saw Goins make a nice backhand stab, then threw to Tulowitzki at second and the double play was completed, as the South Bay native threw to Edwin Encarnacion to end the inning.

It looked like the Giants were about to start a rally in the bottom of the sixth inning, as Jarrett Parker walked to leadoff the inning, went to second on Tomlinson’s second hit of the game; however Parker was thrown out at third base when Cain’s sacrifice attempt was hit right to Happ, who threw to Donaldson for the first out of the frame.

Span ended the inning, he hit into the Giants second double play of the game.

Donaldson’s bid for extra bases was brought to a halt, as Span made a leaping catch at the left-center field wall to end the eighth inning. Happ reached on a opposite field single with one out in the inning.

With a chance to get back in the game in the bottom of the eighth inning, the Giants once came up short.

Parker singled thru the hole at second base with one out, then Tomlinson picked up his third hit of the night and on the play, Parker went to third; however pinch-hitter Trevor Brown struck out looking at a third strike and then Span ended the inning when he flew out to Saunders in left field.

Once again in the bottom of the ninth inning, the Giants started a rally with two outs. Hunter Pence singled, then Brandon Belt and Matt Duffy walked to load the bases. With a chance to tie the game with one swing of the bat, Blue Jays manager John Gibbons took no chances, as he called for his closer Roberto Osuna. The closer did not disappoint his manager, as he struck out Parker on three pitches to end the game.