By Jeremy Kahn

SAN FRANCISCO-Pablo Sandoval continues his hot hitting against that is thrown to him at the plate, and he proved that in his first at-bat of the evening.

Sandoval homered off Samuel Deduno in the bottom of the second inning, as the San Francisco Giants defeated the Minnesota Twins 2-1 before a crowd of 41,724, the 270th consecutive regular season sellout at AT&T Park.

This was the Giants fifth straight win in interleague play against zero losses, as they look to complete their second consecutive interleague sweep on Sunday afternoon.

Last month, the Giants swept the Cleveland Indians from April 25-27 and next face an interleague opponent on June 17, when they travel to the South Side of Chicago to face the Chicago White Sox for a quick two-game series.

It was the fourth home run in the last six games for Sandoval, and continues to stay hot after beginning the season 19-for-114, a .167 clip.

Ryan Vogelsong went 6.2 innings, allowing zero runs on three hits, while walking just one and striking out seven, as he won for the third time this season against two losses.

This was the first interleague for Vogelsong since June 15, 2012, when he defeated the Seattle Mariners at Safeco Field

Over his past six starts, Vogelsong has thrown 40 innings, a 1.35 earned run average with 35 strikeouts.

In his last 13.2 innings, opponents have not scored against the right-hander and the last time he allowed a run was to the Atlanta Braves on May 13, a 5-0 loss at AT&T Park.

Vogelsong did not allow a run to the Miami Marlins on Sunday afternoon in seven innings of work, as the Giants would go to defeat the Marlins 4-1.

Despite the early home run to Sandoval in the bottom of the first inning, Deduno settled down, as he went 5.2 innings, allowing two runs on four hits, walking three and striking out four; however his record fell to 1-3 on the season.

Sandoval added a sacrifice fly in the bottom of the sixth inning, driving Angel Pagan from third base, who led off the inning with a single, advanced to second on a Hunter Pence walk and to third on a Buster Posey Fielders’ Choice that retired Pence at second base.

Josmil Pinto broke up the shutout in the top of the ninth inning, as he took a Sergio Romo over the left field wall for his seventh home run of the season.

Romo settled down to retire Jason Kubel on a groundout to shortstop, Eduardo Escobar struck out for the second and former Oakland A’s catcher Kurt Suzuki ended the game via a groundout to Romo, who picked up his 16th save of the season in 18 opportunities.